| 1. Identificação | ||||
| Tipo de Referência | Artigo em Revista Científica (Journal Article) | |||
| Site | mtc-m21b.sid.inpe.br | |||
| Código do Detentor | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Identificador | 8JMKD3MGP3W34P/3KLJ2B5 | |||
| Repositório | sid.inpe.br/mtc-m21b/2015/11.25.16.17 (acesso restrito) | |||
| Última Atualização | 2015:11.25.16.20.08 (UTC) administrator | |||
| Repositório de Metadados | sid.inpe.br/mtc-m21b/2015/11.25.16.17.53 | |||
| Última Atualização dos Metadados | 2018:06.04.02.55.51 (UTC) administrator | |||
| DOI | 10.1242/jeb.126672 | |||
| ISSN | 0022-0949 | |||
| Chave de Citação | SchuchLiSaSaJaCeLo:2015:MoSeMe | |||
| Título | Molecular and sensory mechanisms to mitigate sunlight-induced DNA damage in treefrog tadpoles  | |||
| Ano | 2015 | |||
| Mês | Oct. | |||
| Data de Acesso | 08 maio 2024 | |||
| Tipo de Trabalho | journal article | |||
| Tipo Secundário | PRE PI | |||
| Número de Arquivos | 1 | |||
| Tamanho | 676 KiB | |||
| 2. Contextualização | ||||
| Autor | 1 Schuch, André P. 2 Lipinski, Victor M. 3 Santos, Maurício B. 4 Santos, Caroline P. 5 Jardim, Sinara S. 6 Cechin, Sonia Z. 7 Loreto, Elgion L. S. | |||
| Grupo | 1 CRS-CCR-INPE-MCTI-GOV-BR | |||
| Afiliação | 1 Instituto Nacional de Pesquisas Espaciais (INPE) 2 Universidade Federal de Santa Maria (UFSM) 3 Universidade Federal de Santa Maria (UFSM) 4 Universidade Federal de Santa Maria (UFSM) 5 Universidade Federal de Santa Maria (UFSM) 6 Universidade Federal de Santa Maria (UFSM) 7 Universidade Federal de Santa Maria (UFSM) | |||
| Revista | Journal of Experimental Biology | |||
| Volume | 218 | |||
| Número | 19 | |||
| Páginas | 3059-3067 | |||
| Histórico (UTC) | 2015-11-25 16:17:53 :: simone -> administrator :: 2018-06-04 02:55:51 :: administrator -> simone :: 2015 | |||
| 3. Conteúdo e estrutura | ||||
| É a matriz ou uma cópia? | é a matriz | |||
| Estágio do Conteúdo | concluido | |||
| Transferível | 1 | |||
| Tipo do Conteúdo | External Contribution | |||
| Tipo de Versão | publisher | |||
| Palavras-Chave | Amphibian decline DNA photoproducts Nucleotide excision repair Photolyases UV radiation | |||
| Resumo | The increased incidence of solar ultraviolet B (UVB) radiation has been proposed as an environmental stressor, which may help to explain the enigmatic decline of amphibian populations worldwide. Despite growing knowledge regarding the UV-induced biological effects in several amphibian models, little is known about the efficacy of DNA repair pathways. In addition, little attention has been given to the interplay between these molecular mechanisms with other physiological strategies that avoid the damage induced by sunlight. Here, DNA lesions induced by environmental doses of solar UVB and UVA radiation were detected in genomic DNA samples of treefrog tadpoles (Hypsiboas pulchellus) and their DNA repair activity was evaluated. These data were complemented by monitoring the induction of apoptosis in blood cells and tadpole survival. Furthermore, the tadpoles' ability to perceive and escape from UV wavelengths was evaluated as an additional strategy of photoprotection. The results show that tadpoles are very sensitive to UVB light, which could be explained by the slow DNA repair rates for both cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6,4) pyrimidone photoproducts (6,4PPs). However, they were resistant to UVA, probably as a result of the activation of photolyases during UVA irradiation. Surprisingly, a sensory mechanism that triggers their escape from UVB and UVA light avoids the generation of DNA damage and helps to maintain the genomic integrity. This work demonstrates the genotoxic impact of both UVB and UVA radiation on tadpoles and emphasizes the importance of the interplay between molecular and sensory mechanisms to minimize the damage caused by sunlight. | |||
| Área | SRE | |||
| Arranjo | Molecular and sensory... | |||
| Conteúdo da Pasta doc | acessar | |||
| Conteúdo da Pasta source | não têm arquivos | |||
| Conteúdo da Pasta agreement |
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| 4. Condições de acesso e uso | ||||
| Idioma | en | |||
| Arquivo Alvo | 2015_such.pdf | |||
| Grupo de Usuários | simone | |||
| Grupo de Leitores | administrator simone | |||
| Visibilidade | shown | |||
| Permissão de Leitura | deny from all and allow from 150.163 | |||
| Permissão de Atualização | não transferida | |||
| 5. Fontes relacionadas | ||||
| Repositório Espelho | urlib.net/www/2011/03.29.20.55 | |||
| Unidades Imediatamente Superiores | 8JMKD3MGPCW/3EUFCFP | |||
| Lista de Itens Citando | sid.inpe.br/bibdigital/2013/10.04.21.53 1 | |||
| Divulgação | WEBSCI; PORTALCAPES; SCOPUS. | |||
| Acervo Hospedeiro | sid.inpe.br/mtc-m21b/2013/09.26.14.25.20 | |||
| 6. Notas | ||||
| Campos Vazios | alternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress electronicmailaddress format isbn label lineage mark nextedition notes orcid parameterlist parentrepositories previousedition previouslowerunit progress project resumeid rightsholder schedulinginformation secondarydate secondarykey secondarymark session shorttitle sponsor subject tertiarymark tertiarytype url | |||
| 7. Controle da descrição | ||||
| e-Mail (login) | simone | |||
| atualizar | ||||